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Figure 2-13: The Default Transition pop-up menu enables you to choose from many preset page transition effects that can be viewed in Full Screen mode.

increased sharing of information and harmonization of activities The International Conference on Harmonization of the Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) (wwwichorg) has been the dominant mechanism for international cooperation among pharmaceutical regulatory authorities in Europe, Japan, and the United States A consensus vision statement was drafted at the July 2003 ICH meeting with regard to the objective of the ICH in harmonizing the efforts of regulatory bodies to establish quality systems approaches in their operations: Develop a harmonized pharmaceutical quality system applicable across the life cycle of the product emphasizing an integrated approach to quality risk management and science.

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However, if the dmap contains more than one channel whether it s a color image or a grayscale image with an independent mask channel the first channel indicates horizontal displacement, and the second channel indicates vertical displacement. All other channels are ignored. Therefore, the Displace filter moves colors that correspond to black areas in the first channel of the dmap to the right and colors that correspond to white areas to the left. (Again, this depends on your specifications in the Displace dialog box.) The filter then moves colors that correspond to the black areas in the second channel downward and colors that correspond to white areas upward. Figure A-31 shows the effect of a two-channel dmap on our friend the pharaoh. The top row shows the appearance and effect of the first channel on the image at 10 percent and 20 percent. The bottom row shows the appearance and effect of the second channel.

Three consensus guidelines de ne the core of the ICH s involvement in harmonization of pharmaceutical quality systems Q8: Pharmaceutical Development, Q9: Quality Risk Management, and Q10: Pharmaceutical Quality Systems (in addition, each of the guidance documents cites critical areas of overlap with Q6A: Speci cations: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances) Q8: Pharmaceutical Development According to the ICH Q8 guideline [58], the aim of pharmaceutical development is to design a quality product and the manufacturing process to deliver the product in a reproducible manner While QbD is not speci cally mentioned in the guideline, the intent of the ICH Q8 expert working group (EWG) was to describe a system that would provide incentive for manufacturers to incorporate aspects of QbD and continuous improvement throughout the product life cycle.

For parallel algorithms dominated by local computation time, dynamic load balancing can be equivalent to minimizing the maximum load. However, for a communicationdominated parallel algorithms, it may be possible that a smaller maximum time can be achieved by distributing work among a subset of processors. Such a situation could have a severe load imbalance, but smaller maximum execution time. Reduction in execution time of an algorithm is achieved through reducing the sum of (1) the maximum time that each processor spends on its computations, (2) the time required for communications, and (3) the time required to determine a new DLB partitioning and migrate data. All three terms must be considered concurrently; for example, it is counterproductive for a DLB operation to reduce the computation time by t, while increasing the communication time by 10 t. This discussion of the interface for DLB is intended to frame concepts for the analysis of an application s use of DLB; however, this discussion is not intended to be that analysis. Per-Processor Computational Time: It is assumed that an application predominantly follows an owner computes rule, where the processor that owns a mesh entity (equation (11.11)) is responsible for the computations associated with that mesh entity. Thus, the variation in the processors computational times can be approximated by the sum of the per-mesh entity computational times. However, work on mesh entities may not be equivalent. For example, an algorithm An may require per-element solution of an ordinary differential equation or have per-element timestepping. Thus, the computational time, or work of a given computation An for a given processor Pk , is a function of the mesh entities being computed on. Tcomp (Pk )

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