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3. Albinism is recessive; assume for this problem that blue eyes are also recessive (albinos have blue eyes). What is the probability that two brown-eyed persons, heterozygous for both traits, would produce (remembering epistasis) a. ve albino children b. ve albino sons c. four blue-eyed daughters and a brown-eyed son d. two sons genotypically like their father and two daughters genotypically like their mother (See also USE OF RULES) 4. On the average, about one child in every ten thousand live births in the United States has phenylketonuria (PKU). What is the probability that a. the next child born in a Boston hospital will have PKU b. after that child with PKU is born, the next child born will have PKU c. two children born in a row will have PKU 5. In fruit ies, the diploid chromosome number is eight. a. What is the probability that a male gamete will contain only paternal centromeres or only maternal centromeres

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For higher-order determinants, you may refer to a linear algebra book To illustrate Cramer s method, a set of two equations in general form will be solved here A set of two linear simultaneous algebraic equations in two unknowns can be written in the form a11 x1 + a12 x2 = b1 a21 x1 + a22 x2 = b2 (A5)

*Answers to selected exercises and problems are on page A-4.

where x1 and x2 are the two unknowns to be solved for The coef cients a11 , a12 , a21 and a22 are known quantities The two quantities on the right-hand side, b1 and b2 , are also known (these are typically the source currents and voltages in a circuit problem) The set of equations can be arranged in matrix form, as shown in equation A6 a11 a21 a12 a22 x1 x2 = b1 b2 (A6)

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In equation A6, a coef cient matrix multiplied by a vector of unknown variables is equated to a right-hand-side vector Cramer s rule can then be applied to nd x1 and x2 using the following formulas: b1 b2 a11 a21 a11 a21 a11 a21 a12 a22 a12 a22 (A7) b1 b2 a12 a22

The McGraw Hill Companies, 2001

Force (F)

x1 =

7. 8.

x2 =

Thus, the solution is given by the ratio of two determinants: the denominator is the determinant of the matrix of coef cients, while the numerator is the determinant of b1 the same matrix with the right-hand-side vector ( in this case) substituted in b2 place of the column of the coef cient matrix corresponding to the desired variable (ie, rst column for x1 , second column for x2 , etc) In a circuit analysis problem, the coef cient matrix is formed by the resistance (or conductance) values, the vector of unknowns is composed of the mesh currents (or node voltages), and the right-hand-side vector contains the source currents or voltages

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b. What is the probability that a zygote will contain only centromeres from male grandparents (Disregard the problems that the sex chromosomes may introduce.) How many seeds should Mendel have tested to determine with complete certainty that a plant with a dominant phenotype was heterozygous With 99% certainty With 95% certainty With pretty reliable certainty What chance do a man and a woman have of producing one son and one daughter PKU and albinism are two autosomal recessive disorders, unlinked in human beings. If two people, each heterozygous for both traits, produce a child, what is the chance of their having a child with a. PKU b. either PKU or albinism c. both traits In human beings, the absence of molars is inherited as a dominant trait. If two heterozygotes have four children, what is the probability that a. all will have no molars b. three will have no molars and one will have molars c. the rst two will have molars and the second two will have no molars (See also USE OF RULES) Galactosemia is inherited as a recessive trait. If two normal heterozygotes produce children, what is the chance that a. one of four children will be affected b. three children will be born in this order: normal boy, affected girl, affected boy

In practice, many calculations involve solving higher-order systems of linear equations Therefore, a variety of computer software packages are often used to solve higher-order systems of linear equations

The Resistance Ratio,

A3 Convert the following system of linear equations into a matrix equation as shown in equation A6 and nd matrices A and b

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