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multiple and usually present with a clinical syndrome related to hypersecretion of a native or ectopic hormonal product The endocrine diagnosis of a particular pancreatic islet neoplasm depends on first suspecting it from its clinical manifestations Many tumors secrete two or more different hormones Insulinomas are usually (about 82%) benign and secrete excessive amounts of insulin (as well as proinsulin and Cpeptide), which causes hypoglycemia The tumors may be multiple, especially in familial MEN 1 about 12% of cases (see 27) Gastrinomas secrete excessive quantities of the hormone gastrin (as well as big gastrin), which stimulates the stomach to hypersecrete acid, thereby causing hyperplastic gastric rugae and peptic ulceration (Zollinger Ellison syndrome) Most gastrinomas are benign, but some are malignant and metastasize to the liver Gastrinomas are typically found in the duodenum (49%), pancreas (24%), or lymph nodes (11%) Presenting symptoms and signs include abdominal pain (75%), diarrhea (73%), heartburn (44%), bleeding (25%), or weight loss (17%) Endoscopy usually discovers prominent gastric folds (94%) Sporadic Zollinger Ellison syndrome is rarely suspected at the onset of symptoms; typically, there is a 5-year delay in diagnosis About 22% of patients have MEN 1 MEN 1 usually presents in patients who are younger; hyperparathyroidism may occur from 14 years preceding the Zollinger Ellison diagnosis to 38 years afterward (See Multiple Endocrine Neoplasia, below) Therapy with high doses of proton pump inhibitors (quadruple usual doses) is usually effective Surgery is not usually performed because of the low cure rates, particularly in patients with MEN 1 Note that serum gastrin levels tend to be high in any patient who is taking a proton pump inhibitor; hypercalcemia also stimulates gastrin release The 5-, 10-, and 20-year survival rates with MEN 1 are 94%, 75%, and 58%, respectively, while the survival rates for sporadic Zollinger Ellison syndrome are 62%, 50%, and 31%, respectively (See 14) Glucagonomas are usually malignant; weight loss and liver metastases are ordinarily present by the time of diagnosis They usually secrete other hormones besides glucagon, often gastrin Other initial symptoms often include diarrhea, nausea, peptic ulcer, or necrolytic migratory erythema About 35% of patients ultimately develop diabetes The median survival is 28 years after diagnosis Somatostatinomas are very rare and are associated with weight loss, diabetes mellitus, malabsorption, and hypochlorhydria Other rare tumors secrete excessive amounts of vasoactive intestinal polypeptide (VIP), a substance that causes profuse watery diarrhea (Verner Morrison syndrome) Treatment with octreotide improves the symptoms but does not halt tumor growth Symptomatic improvement with calcitonin treatment has also been reported Islet cell tumors can secrete ectopic hormones in addition to native hormones, often in combinations producing a variety of clinical syndromes They may secrete ACTH, producing Cushing s syndrome Secretion of serotonin can produce an atypical carcinoid syndrome manifested by pain, diarrhea, and weight loss; skin flushing occurs in only 39% of patients.

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Perry, Bruce W. AppleScript in a Nutshell: A Desktop Quick Reference. Sebastopol, CA: O Reilly, 2001. Peterson, James Lyle, and Abraham Silberschatz. Operating System Concepts. Reading, MA: Addison-Wesley, 1985. Pogue, David. Mac OS X: The Missing Manual. 2nd ed. Sebastopol, CA: Pogue Press/ O Reilly, 2002. Ritchie, Dennis. N. The UNIX Time-sharing System A Retrospective. . Reflections on Software Research. Paper read at The UNIX Review, 1985. Salus, Peter H. A Quarter Century of UNIX. Reading, MA: Addison-Wesley, 1994. S nchez, Wilfredo. The Challenges of Integrating the Unix and Mac OS Environments. Paper presented at the USENIX 2000 Annual Technical Conference, Invited Talks, San Diego, June 19, 2000. http://www.mit.edu/people/wsanchez/papers/USENIX_2000. Siewiorek, Daniel P., C. Gordon Bell, and Allen Newell, eds. Computer Structures: Principles and Examples. New York: McGraw-Hill, 1982. Silberschatz, Abraham, Peter B. Galvin, and Greg Gagne. Operating System Concepts. 6th ed. New York: John Wiley & Sons, 2002. Steinberg, Gene. Mac OS X version 10.1 Little Black Book. Scottsdale, AZ: Coriolis Group, 2002. Stephenson, Neal. In the Beginning Was the Command Line. New York: Avon Books, 1999. Sydow, Dan Parks. Mac OS X Programming. Indianapolis: New Riders, 2002. . Macintosh Programming Techniques: A Foundation for All Macintosh Programmers. New York: M&T Books, 1994. Tanenbaum, Andrew S. Modern Operating Systems. 2nd ed. Upper Saddle River, NJ: Prentice Hall, 2001. Tanenbaum, Andrew S., and Albert S. Woodhull. Operating Systems: Design and Implementation. 2nd ed. Upper Saddle River, NJ: Prentice Hall, 1997. Van der Linden, Peter. Expert C Programming! Englewood Cliffs, N.J.: SunSoft Press, 1994. Wilde, Ethan. AppleScript for Applications. Berkeley, CA: Peachpit Press, 2002. Varian, Melinda. VM and the VM Community: Past, Present, and Future. 1997. Vyssotsky, Victor. Putting UNIX in Perspective: An Interview with Victor Vyssotsky. By Ned Pierce. Paper read at The UNIX Review, 1985.

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