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45 Kobayashi S, Takehana M, Itoh S, et al Protective effect of magnesium-L-ascorbyl-2-phosphate against skin damage induced by UVB irradiation Photochem Photobiol 1996;64:224 46 Geesin JC, Gordon JS, Berg RA Regulation of collagen synthesis in human dermal broblasts by the sodium and magnesium salts of ascorbyl-2phosphate Skin Pharmacol 1993;6:65 47 Kameyama K, Saka C, Kondoh S, et al Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VCPMG) on melanogenesis in vitro and in vivo J Am Acad Dermatol 1996;34:29 48 Ikeno H and Ohmori K Clinical study of safety and ef cacy of 5% sodium L-ascorbyl-2 phosphate lotion to treat acne scars after glycolic acid peels Cosmet Dermatol 2003;1:29 49 Ikeno J, Nishikawa T Clinical evaluation of topical sodium-L-ascorbyl-2-phosphate lotion (5% w/v) in patients with acne Paper presented at: 3rd Annual Meeting of The Society for Investigative Dermatology; May 15-18, 2002; Los Angeles, CA 50 Ochiai Y, Kaburagi S, Obayashi K et al A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its antioxidative properties J Dermatol Sci 2006;44:37 51 Packer JE, Slater TF, Willson RL: direct observation of a free radical interaction between vitamin E and vitamin C Nature 1979;278:737 52 Stoyanovsky DA, Osipov An, Quinn PJ, et al Ubiquinone-dependent recycline of vitamin E radicals by superoxide Arch Biochem Biophys 1995; 323:343 53 Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S Vitamin E: critical review of its current use in cosmetic and clinical dermatology Dermatol Surg 2005;31:815 54 Baumann LS, Spencer J The effects of topical vitamin E on the cosmetic appearance of scars Dermatol Surg 1999;25:311 55 Jenkins M, Alexander JW, MacMillan BG, et al Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery J Burn Care Rehabil 1986;7:309 56 Alberts DS, Goldman R, Xu MJ, et al Disposition and metabolism of topically administered alpha-.

Because P is symmetric positive de nite, there exists orthonormal matrix U and positive de nite diagonal matrix such that P = U 2 U The units of the diagonal elements of = diag([ 1 , 2 , 3 ]) are meters To simplify the analysis, we introduce a new random variable v = Sw where S = 1 U The covariance matrix for v is the identity matrix which is shown as follows: E vv = E Sww S = SPS = 1 U = I Therefore, v N (0, I) The probability density function for v is pv = 1 (2 )

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The components of the vector v are independent and identically distributed with variance equal to one The components of v are dimensionless Given the previous de nitions and a positive scalar c, we have the following relationships P rob{ v c} = P rob{w S Sw c2 } = P rob{w P 1 w c2 } We will nd the value of c such that the sphere in the v coordinates with radius c contains 50% of the v samples In the w coordinates the region expected to contain 50% of the w samples will be the ellipsoid

w R3 w P 1 w c2 Because w = U v and U is an orthonormal matrix, the columns of U de ne the principle axes of the ellipsoid and the diagonal elements of de ne the elongation of the ellipsoidal axes For example, if U = [u1 , u2 , u3 ] where ui is the i-th column of U, then a unit vector along the i-th coordinate axis of the v reference frame transforms to the vector ( i ui ) in the w reference frame The probability that v falls in the region v c can be derived as P rob{ v c} =

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