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Seizure disorders are the most frequent major neurologic complications encountered in pregnancy and more than 95% of patients who have seizures during pregnancy have a history of epilepsy or have been receiving anticonvulsant therapy What are the two major pregnancyrelated threats to women with epilepsy Increased seizure frequency is associated with subtherapeutic anticonvulsant levels and/or a lower seizure threshold What are the several factors that cause these characteristics Increase in seizure frequency Increased risk of congenital malformations in the fetus Pregnancy-related changes such as nausea and vomiting, decreased gastrointestinal motility, increased intravascular volume, increased drug metabolism from induction of hepatic and placental enzymes, antacid use (reduces drug absorption because of abnormal protein binding), and increased glomerular filtration rate decrease anticonvulsant concentrations Decreased seizure threshold can be affected by sleep deprivation, and hyperventilation and pain during labor

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11 of Orange Book, which describes the recordable forms of disc, de nes a hybrid disc variation that consists of a mastered rst session and a second recordable session In Mitsui s approach, the rst session contains an AUTORUNINF le that will launch the installer to put the backup program driver on your system (if the auto-insert noti cation feature is turned on in the Windows operating system) Once the driver is installed, inserting a disc automatically brings up the backup program, allowing you to access all of the backup and restore features of the program The producer of the backup application, Veritas (wwwveritascom), also offers other backup applications, some of which are easily adaptable to optical disc recording Kodak has taken this same principle the ability to generate a multi-session recordable disc and created a product called CD-PROM The original discs employ a recorded rst session, in addition to the recordable areas of the disc, but Kodak s plans are to incorporate mastered rst sessions The rst session of this type of hybrid disc could contain many different sorts of applications Cataloging and indexing programs would be especially useful to anyone archiving different types of data to recordable disc Encoders for MP3 music or compression utilities for video or graphics could be handy The hybrid CD may become an important vehicle for adding extra value to recordable media one more means for a manufacturer to separate themselves from the competition

What are the maternal and fetal side effects for the following traditional anticonvulsant medications

We could also have used the following inline notation:

As CD recorder speeds continue to ramp up, the issue of media responsiveness to high-speed recording becomes more critical Many of the speci cations in the Orange Book were designed in the days of low-speed recording and the issues become somewhat different when 8x and 10x recorders come into play The introduction of 12x recorders makes the issue even more important Media that have been tested for high-speed recording speeds are crucial to recording integrity In particular, a dye formulation that can meet the demands of the higher recording speeds is key to the process Thinner dye layers that have been optimized for high speeds must also be able to operate effectively when recording speeds drop down to 1x levels Check the recommendations included in your CD-R or DVD-R operator s manual for guidelines as to what will work and what won t Many of the recorder manufacturers will list one or two recommended media types, giving you some assurance that they have actually tested the media and found it compatible with their equipment

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Fetal Side Effects Fetal hydantoin syndrome: craniofacial anomalies (upturned nose, mild midfacial hypoplasia, thin philtrum, facial clefts), fingernail hypoplasia, growth deficiency, developmental delay, cardiac defects Fetal hydantoin syndrome, spina bifida, fingernail hypoplasia, IUGR Neural-tube defects, heart and kidney malformations, hypospadia, polydactyly Clefts, cardiac anomalies, urinary tract malformations Possible teratogenesis, coagulopathy, neonatal depression

This approach is more concise, but it s harder to read. In either case, we get the results we want (figure 12.6). You might also notice that we ve added a MinWidth and a Right TextAlignment so that our values will line up on the right edge.

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