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The pathogenic basis of the neuropathy is not known but may be related to the amphiphilic properties of the drug Chloroquine contains both hydrophobic and hydrophilic regions that allow chloroquine to interact with the anionic phospholipids of cell membranes and organelles This drug lipid complex may be resistant to digestion by lysosomal enzymes, leading to the formation of autophagic vacuoles lled with myeloid debris that may, in turn, cause degeneration of nerves and muscle bers

Notice that rolls was declared using square brackets, telling the compiler that rolls is a pointer to the first element of an array (in this case, to an array of ints):

Hydroxychloroquine is structurally similar to chloroquine and not surprisingly has also been associated with a toxic neuromyopathy8 Weakness and histological abnormalities are usually not as severe as seen in chloroquine myopathy Vacuoles are typically absent on

as a property of the parent movie clip The following code demonstrates an example of modifying the X position of the movie clip child_mc that is within the movie clip parent_mc

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Sensory NCS reveal markedly reduced amplitudes and, when obtainable, mild to moderately slow conduction velocities and prolonged distal latencies11,13 15 Motor NCS may also be abnormal but usually not to the same degree as sensory studies EMG demonstrates brillation

void int PrintRolls( int rolls[] ) { i;

potentials, positive sharp waves, and occasionally myotonic discharges with a mixture of myopathic and neurogenic appearing MUAPs

Podophyllin is a topical agent used to treat condylomata acuminata Systemic side effects include gastrointestinal paresis, urinary retention, pancytopenia, and liver and renal dysfunction19 23 Podophyllin is also potentially toxic to both the central and the peripheral nervous systems, leading to psychosis, altered consciousness, and polyneuropathy The neuropathy is characterized by slowly progressive sensory loss, paresthesias, muscle weakness, and diminished muscle stretch re exes in length-dependent pattern Autonomic neuropathy with nausea, vomiting, constipation, urinary retention, orthostatic hypotension, and tachycardia may also occur The signs and symptoms of this toxic neuropathy can progress for a couple months even after stopping the medication The neuropathy gradually improves with discontinuation of the podophyllin, but it can take several months to over a year and residual de cits may remain

parent_mcchild_mc_x = 10;

The for loop steps through the rolls array, one int at a time, starting with rolls[2] and making its way to rolls[12]. For each element, PrintRolls() first prints the roll number and then, in parentheses, the number of times (out of 1,000) that roll occurred. Next, PrintX() is called to print a single x for every ten rolls that occurred. Finally, a carriage return is printed, preparing the console window for the next roll:

Muscle biopsies demonstrate autophagic vacuoles with myeloid and dense inclusions on EM and neurogenic atrophy, particularly, in distal muscles Sural nerve biopsies demonstrate a combination of segmental demyelination and axonal loss EM reveals lamellar or dense inclusions in Schwann cells, pericytes, and endothelial cells The inclusions in muscle and nerve biopsies have persisted as long as 2 years following discontinuation of the medication

The pathogenesis is presumably similar to other amphiphilic medications (eg, chloroquine)

for ( i=2; i<=12; i++ ) { printf( "%2d (%3d): ", i, rolls[ i ] ); PrintX( rolls[ i ] / 10 ); printf( "\n" ); } }

Colchicine is used primarily to treat patients with gout and is also associated with a toxic neuropathy and myopathy16 18 Affected individuals usually present with proximal weakness and numbness and tingling in the distal extremities Reduced sensation to touch, vibration, and position sense and diminished muscle stretch re exes are found on examination

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