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ies with valacyclovir (500 mg daily for 8 months) show a nearly 50% reduction in acquisition of disease and a 75% reduction in clinical disease among the HSV-2 discordant heterosexual partners The advantages of these two agents include higher serum levels and less frequent administration AIDS patients with a history of mucocutaneous disease should receive lifelong suppressive therapy Acyclovir resistance occurs often among immunodeficient persons Counseling, barrier protection or, in the future, microbicides, are useful to decrease the rate of transmission among sexual partners of infected persons HIV-infected individuals should be assayed for HSV-2 serologies and counseled if seropositive In addition, among HIV-infected persons, the use of highly active antiretroviral therapy (HAART) is associated with fewer days of HSV-1 or -2 lesions
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Ophthalmic trifluridine, vidarabine, and acyclovir given as drops for 10 days (without corticosteroids) are the available alternatives Long-term (greater than 1 year) treatment with acyclovir at a dosage of 800 mg/d orally decreases recurrence rates Future treatment may entail use of angiogenesis modulators
Acyclovir intravenously is effective for disseminated lesions in neonatal disease The dosage is 20 mg/kg intravenously every 8 hours for 14 21 days The use of maternal antenatal suppressive therapy with acyclovir (typically, 800 mg/day) beginning at 36 weeks gestation decreases rates of HSV detection, asymptomatic shedding, and recurrence at delivery or need for cesarean section However, cesarean section is recommended for pregnant women with active genital lesions or typical prodromal symptoms
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Varicella zoster virus (VZV) is HHV-3 Disease manifestations are either chickenpox (varicella) or shingles (herpes zoster) Chickenpox is highly contagious and is generally a disease of childhood, with spread by inhalation of infective droplets or contact with lesions after an incubation of 10 20 days (average, 14 15 days) The incidence and severity of herpes zoster ( shingles ) increases with age (although cases are reported among infants and children) due to an age-related decline in immunity against VZV More than half of all patients in whom herpes zoster develops are older than 60 years The annual incidence of herpes zoster in the United States is at least 1 million cases, which is expected to increase as the population ages Other persons at risk include those who are immunosuppressed (eg, patients receiving cancer treatment, patients with AIDS, and organ transplant recipients) and occasionally infants after intrauterine infection
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