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suffering side effects from the treatment When medication is stopped in this population, most patients drop back to their pretreatment nadir CD4 count in a matter of months Some patients whose counts rise dramatically and who are fully suppressed (ie, plasma viral load < 50 copies/mcL) may be successfully transitioned from a high potency regimen to a lower potency regimen with fewer side effects; however, this induction-maintenance strategy is still being evaluated in clinical trials Once a decision to initiate therapy has been made, several important principles should guide therapy First, because drug resistance to antiretroviral agents develops in HIVinfected patients, a primary goal of therapy should be complete suppression of viral replication as measured by the serum viral load Therapy that achieves a plasma viral load of < 50 or < 75 copies/mcL (depending on the test used) has been shown to provide a durable response to the therapy To achieve this and maintain virologic control over time, combination therapy with at least 3 drugs is necessary, and partially suppressive combinations such as dual nucleoside therapy should be avoided Similarly, if toxicity develops, it is preferable to either interrupt the entire regimen or change the offending drug rather than reduce individual doses The current standard is to use at least three agents simultaneously usually from at least two different classes Because the number of drugs and potential combinations is finite and the development of drug resistance may severely compromise the efficacy of treatment, patients must be able to adhere to these regimens Adherence can be promoted through the use of medication boxes with compartments (eg, Medisets), supportive counseling, or daily supervision of therapy Therefore, decisions to withhold treatment should not be based on a patient s circumstances (eg, active drug use or housing status) alone Often, a trial intervention such as offering Pneumocystis pneumonia prophylaxis may be helpful in determining the likelihood of adherence to a more complex antiretroviral regimen Monitoring of antiretroviral therapy has two goals Laboratory evaluation for toxicity depends on the specific drugs in the combination but generally should be done approximately every 3 months once a patient is on a stable regimen The second aspect of monitoring is to regularly measure objective markers of efficacy The CD4 cell count and HIV viral load should be repeated 1 2 months after the initiation or change of antiretroviral regimen and every 3 4 months thereafter in clinically stable patients Reasons for changing antiretroviral regimens include intolerable adverse reactions, rising or persistently detectable viral loads, the clinical progression of disease, and continued immunologic deterioration as reflected by a declining CD4 cell count Although a rebound in HIV viral load is cited as an indication to change therapy, exact parameters have not been established, and many patients appear to have continued clinical benefit in the face of rising viral load measurements When therapy is modified, clinicians should attempt to start at least two agents to which an individual has not been exposed or to which there is minimal or no resistance at the same time Conversely, there is a risk to stopping a single medication because of the possibility of its causing a side effect if the remaining regimen contains too few medications to prevent rapid development of resistance.

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Getting Started. This section explains how to add and use a PDF viewer control in your web application with ASP.NET MVC .

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E5101 - How to implement a simple PDF viewer in ASP . NET MVC ...
1 Mar 2019 ... This example demonstrates how to implement a custom web PDF viewer control by using the Office File API functionality. The main idea of this ...

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