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A subset of children demonstrate symptoms re ective of the traumatic nature of cancer diagnosis and treatment (Kazak et al, 2001) Predominant studies have found rates of posttraumatic symptoms in 16% to 21% (Stuber, 2006) of childhood cancer survivors These ndings have indicated several factors that seem to increase the chances that PTSD concerns will arise in certain children, including age, female gender, family and social support, history of previous trauma, the child s level of anxiety, experience of painful or traumatic experiences during the treatment process, and his or her subjective appraisal of the threat of the illness (Apter et al, 2003; Stuber & Kazak, 1999) Consistent with Noll and Kupst s (2007) contention of hardiness, however, research suggests that survivors of childhood cancer demonstrate fewer PTSD symptoms than survivors of other stressful events (Phipps et al, 2005).

Numbers mark aspects of the case most consistent with DSM criteria, and do not necessarily indicate that the case meets diagnostic criteria in this respect.

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Most investigations of the psychological impact of cancer diagnosis and treatment on pediatric survivors have found that the majority of survivors are functioning well (Noll & Kupst, 2007; Stuber & Kazak, 1999) Within this group of children, several areas of psychosocial adjustment have been shown to be relatively resilient in the face.

One of the goals of Step Two is getting inventory accuracy to real time that is, having inventory counts that ref lect what a company actually has on hand moment to moment, as close to instantaneously as possible.

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Gyapay, G, et al, A Radiation Hybrid Map of the Human Genome, Hum Mol Genet, 5, 339 346 (1996) Hadi, M, et al, Functional Characterization of Ape1 Variants Identi ed in the Human Population, Nucl Acids Res, 28, 3871 3879 (2000) Halushka, MK, et al, Patterns of Single-Nucleotide Polymorphisms in Candidate Genes for Blood-Pressure Homeostasis, Nat Genet, 22, 239 247 (1999) Hayward, C, et al, Molecular Genetic Analysis of the APEX Nuclease Gene in Amyotrophic Lateral Sclerosis, Neurology, 52, 1899 1901 (1999) Hedenfalk, I, et al, Gene-Expression Pro les in Hereditary Breast Cancer, N Engl J Med, 344, 539 548 (2001) Hogenesch, JB, et al, A Comparison of the Celera and Ensembl Predicted Gene Sets Reveals Little Overlap in Novel Genes, Cell, 106, 413 415 (2001) Hustert, E, et al.

self-critical conscience. Depressives, however, feel overwhelmed by their troubles, are resigned to their suffering, and are often satisfied to ruminate alone. In contrast, the masochist requires a partner, a persecutor, and will create one when necessary by exaggerating ordinary human conflicts, investing others with hidden motives, and then reacting with either indignation, a feature shared with the paranoid (McWilliams, 1994), or massive self-pity. Moreover, masochism often hides a sadistic purpose that the depressive lacks: The persecutor must be persecuted for being the persecutor. Acting out their conflicts gives masochists a greater sense of energy than is possessed by the lethargic depressive. Comparisons and contrasts can also be made with the dependent, compulsive, and borderline personalities. Both the masochist and dependent are submissive, overtly noncompetitive, and bond parasitically to their partner. Dependents, however, return affection with affection and give of themselves to further strengthen their enmeshments. In contrast, masochists give their all to put their dedication on public view, capitalize on their own self-pity, cast the recipients of their kindnesses in the role of being insufficiently appreciative, or else achieve a super-enmeshment that cannot be denied. Both masochists and compulsives have strong underlying guilt feelings. The masochist, however, elicits punishment, whereas the compulsive greatly fears it. Finally, both masochists and borderlines sometimes share a tendency toward self-mutilation. Masochists, however, mutilate to undo their own guilt, whereas borderlines mutilate more to confirm their existence and forestall identity diffusion. Moreover, borderlines react frantically to the possibility of abandonment, whereas masochists sometimes use abandonment either to confirm their low self-worth and evoke self-pity or to display further evidence of their misfortune to others.

An article about CoPs on the Intelligent KM site12 suggests examples of these extracurricular but relevant communities, such as multimedia application development at a software company, herbal remedies found in the Amazon rain forest at the National Institutes of Health (NIH), or aerodynamic automobile design at a car manufacturer In all of these cases, hobbyists would come together to share resources and attempt to answer each other s questions while advancing collective knowledge Often, a CoP coalesces around an acknowledged leader in the field: an expert or master who helps train eager apprentices Members of the community bring new knowledge to it and, through cultural osmosis, into the sponsoring organization Because CoPs are more concerned with learning and innovation than execution and productivity, they may seem to run counter to the priorities of the businesses that sanction them.

, Natural Protein Variants of Pregnane X Receptor with Altered Transactivation Activity Toward CYP3A4, Drug Metab Dispos, 29, 1454 1459 (2001) Ingelman-Sundberg, M and WE Evans, Unraveling the Functional Genomics of the Human CYP2D6 Gene Locus, Pharmacogenetics, 11, 553 554 (2001) Kalow, W, Pharmacogenetics, Pharmacogenomics, and Pharmacobiology, Clin Pharm Ther, 70, 1 4 (2001a) Kalow, W, Pharmacogenetics in Perspective, Drug Metab Dispos, 29, 468 470 (2001b) King, M-C, Leaving Kansas Finding Genes in 1997, Nat Genet, 15, 8 10 (1997) Lai, E, Application of SNP Technologies in Medicine: Lessons Learned and Future Challenges, Genome Res, 11, 927 929 (2001) Lander, ES, et al, Initial Sequencing and Analysis of the Human Genome, Nature, 409, 860 921 (2001) Liang, F, et al, Gene Index Analysis of the Human Genome Estimates Approximately 120,000 Genes, Nat Genet.

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