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introduced it to the Giants that summer and made it a prominent part of his offensive game plan When it came to the Sweep, my father was relentless He drilled that play into the soul of every player on the offense He went over it again and again, chalk in hand, reviewing every assignment He would sell and resell the goal of the play This is the lead play in our offense, he d say, We must make it go We will make it go We will run it again and again and again, and we will make it go The one [play] everybody remembers most, coach and commentator John Madden later recalled, is what came to be known as the Lombardi Sweep Paul Hornung takes a handoff from Bart Starr and runs to his right behind the block of Jim Taylor, the fullback, and Jerry Kramer and Fuzzy Thurston, the two guards who had pulled out of the line The success of the Packer offense depended on the success of this one play If everyone performed as the play was designed, the team succeeded, but if just one assignment was missed, the play would fail The Packers would run the Sweep over and over, challenging their opponents to stop them Inevitably, in adjusting to the Sweep, the opposing defense would leave themselves vulnerable to other plays in the Packer playbook If you couldn t stop the Sweep, you couldn t beat the Packers Quarterback Bart Starr watched my father get up at the blackboard and diagram this sequence of assignments 11 assignments, one for each player on the offense every summer for nine straight years He said that it was a brilliant performance, which captivated him every time he saw it

cations utilizing GPS, a worldwide network of 24 satellites transmitting precise location data, have been available since the mid-1980s GPS chipsets are being integrated into pagers, cellular and satellite phones, as well as trunked radios, and walkie-talkies Some systems now unify the GPS chipset with a two-way radio using a single IP compliant processor, enabling a system to use the Internet and ubiquitous two-way paging networks to achieve real-time location data delivery (Brenda Lewis, Location, Location, Location: The Killer App for Mobile E-Commerce " in WirelessAgenda2000, Session #B6, Conference Proceedings, published by The Wireless Data Forum WDF/CTIA 2000)

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6 This potential problem may be less than previously thought if most of the potassium secretion occurs early in the distal nephron (connecting tubule), rather than in the more distal regions (collecting ducts) This is because the major reabsorption of water that concentrates luminal potassium and other solutes in the collecting ducts has not yet occurred in the connecting tubule

There s nothing spectacular about it It s just a yard-gainer, and I ve diagrammed it so many times and coached it so much and watched it evolve so often since I first put it in with the Giants eight years ago that I think I see it in my sleep

low potassium ingestion there are few ROMK channels in the apical membrane Another adaptation to prolonged periods of low potassium ingestion is an increase in H-K-ATPase activity in intercalated cells, resulting in even more efficient reabsorption of filtered potassium

Wireless LAN architecture is focused deeply on the enterprise today It is designed principally for networking and general business applications within a flexible enterprise space Wireless LANs can be used principally to provide PCs with wireless connections to a corporation s computing infrastructure of servers, gateways, and web sites The technology has become popular in warehousing and manufacturing, but could become an advanced form of white-collar office mobile office automation Alternately, wireless LANs can be an integral part of the transaction processing systems with an enterprise These LANs may interactively track the movement of inventory, assets, and value-added processing within the manufacturing facility, shipping dock, or warehouse, starting with data collection by the worker In these applications, technicians use a handheld terminal eg, bar code scanners, digital image scanners, and/or a ruggedized handheld data collection device, which interfaces via a short-range piconet (Personal Area Network) to access points of the larger enterprise LAN In this way, the wirelessly enabled LAN brings" the interactive and transactional capabilities of the host computer to the worker s site A combination of PAN and LAN capability helps direct and organize the transactions of the work process, aiding in workers productivity

W H AT I T TA K E S T O B E # 1

We begin this section by mentioning a potential problem in the renal handling of potassium that in healthy kidneys is not a problem The potential problem is the simultaneous balance of sodium and potassium Normal human diets contain variable amounts of sodium and potassium, and the kidneys have to handle any combination of loads: both high, both low, one high, and the other low Given that so much of the transport of these ions is by coupled mechanisms it is remarkable that the kidneys can deal with every combination This is all the more remarkable when we consider that aldosterone is a regulator of both If a person is consuming little salt of any kind (low loads of both sodium and potassium), then we expect, in order to preserve body stores of sodium, to see aldosterone levels high enough to stimulate avid reabsorption of sodium But this should also lead to avid secretion of potassium, which is an unwanted action as the body is also trying to conserve potassium The answer is simply that potassium cannot be secreted unless there are open channels If the actions of intracellular signaling cascades has caused most of the ROMK channels to be sequestered in intracellular vesicles, then potassium that is taken up from the interstitium via the Na-K-ATPase recycles back to the interstitium and is not secreted

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