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Interestingly, this survey identified only one priority contributing to core strategy for which top managers and controllers have even slightly different expectations. Here, what the survey calls decision makers rated this priority as third most important, with a 3.8 rating. In contrast, so-called decision enablers rated this priority in fifth place, with a 3.5 score. In doing so, they also rated contributing to core strategy below the priorities of improving processes (3.7) and setting standards (3.6). Other information in the E&Y/IMA survey suggests why controllers rate contributing to core strategy as a lower priority than do CEOs. In particular, this survey asked respondents to identify factors that distort true cost calculation in their organizations. Background: 98% of respondents acknowledged some cost distortion in their reports, with 38% deeming these distortions significant. The survey identified the sources of these cost distortion problems as: Distortions from overhead allocations: causes mild distortion, 50%; causes significant distortion, 35% Shared services: mild distortion, 59%; significant, 23% Greater product diversity: mild, 45%; significant, 25% Increasing IT expenditure: mild, 55%; significant, 15% Greater customer diversity: mild, 43%; significant, 18%

Immunological defences have proven to be sensitive markers of exposures to environmental contaminants (Bayne & Moore, 1997) Such internal defences are not restricted to vertebrates Natural history traits of several invertebrate species predispose them to serving as excellent sentinels for pollutants For bivalve molluscs in particular, combined ecological and physiological traits predispose them to serve as ideal models for studies in immunotoxicology (Bayne & Moore, 1997) Mussels, clams and oysters have proven suitable for assays at the levels of Tier I (molecules and cells), Tier II (cells and tissues) and Tier III (host resistance challenge) (see 4) Here, Tier I assays in molluscs are considered as they yield the most clear-cut and interpretable data on effects of xenobiotics.

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Ramsey Clark, the former Attorney General of the United States, spoke on behalf of many root cause theorists in his 1970 book, Crime in America Among the major factors he saw promoting social dysfunction and crime increases were population growth, concentration of minorities and the poor into slums, economic disparities, poor housing, lack of adequate social assistance, disease, despair, mental retardation, lack of proper education, discrimination, and unemployment22 Interestingly, advances in medicine and the ability to better understand the functioning of the human brain have also contributed to more recent developments in root cause theory Malcolm Gladwell, in a 1997 New Yorker article called Damaged, cited medical studies and research as providing indications that some violent criminals have suspicious histories of child abuse, brain injuries, and psychotic symptoms that may explain some of their subsequent acts23 Clark and Gladwell have somewhat abundant company.

which may need to be satis ed for any i 1 i m and any case ep 2 LEi for generating m clusters. Inequality (3.31) means that the similarity between a case and the cluster to which it actually belongs is greater than the similarity between that case and any other cluster. 3.4.2 Fuzzy ID3 Algorithm for Classi cation

Measurements of lysosomal accumulation and retention of foreign chemicals have proven to be easy means to obtain data on the health status of cells, and on the level of expression of multixenobiotic resistance transporter proteins Both of these are prognostic for more debilitating effects of prolonged and heavier exposures to toxic chemicals (Bayne & Moore, 1997) Additional assays which have been used productively in environmental toxicology with these animals include measurements of induced metal-binding proteins (metallothioneins), induced enzymes with oxygenscavenging activities (superoxide dismutase, catalase) and metabolising activities for polychlorinated hydrocarbons (cytochromes P450), phagocytosis, respiratory burst and the plasma concentrations of various humoral factors (see Bayne & Moore, 1997) In the speci c context of molluscan blood cells, these latter are generally rich in lysosomes, phagocytically active and highly responsive to pollutant chemicals (Grundy et al, 1996a,b; Lowe et al, 1995a,b; Moore et al, 1996a,b; Viarengo et al.

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