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2 Muscle diseases in which an inherited biochemical defect is present. Specific enzyme deficiencies occur which disrupt the pathways of carbohydrate or fat oxidation, often with accumulation of substrate within the muscle cell. The enzyme deficiency may be within the muscle cell cytoplasm, interfering with the utilization of glycogen or glucose, or it may be within the mitochondria of muscle cells (and cells of other organs) blocking the metabolism of pyruvate, fatty acids or individual elements of Krebs cycle. In other diseases of this sort, there is uncoupling of the electrical excitation of muscle fibres and their contraction. This is the case in McArdle's syndrome, and in malignant hyperpyrexia where sustained muscle contraction may occur in the absence of nerve stimulation.

Legends give references for a chart or table. They aren t a main topic of interest. Keep them small and out of the way. Reduce their clutter by reducing the size of their fonts, removing their boxes and background shading, and moving them out of the visual focus.

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Note that volumetric risk is present in each of these factors either through the load requirement, L, or the capacity term, K. The risk in this portfolio is the standard deviation. For convenience, we compute the variance with the understanding that the risk is the square root of the variance. Using Formulas 1, 2, and 3 from Section 10.3, we obtain the following expression for the variance. Var(R) = (p n)2Var(L) + Var(LP) + Var(D) + Var(I) + Var(K) 2(p n)(Cov(L,LP) 2Cov(L,D) 2Cov(L,I)) 2(p n)Cov(L,K) + 2Cov(LP,D) + 2Cov(LP,I) + 2Cov(LP,K ) + 2Cov(D,I) + 2Cov(D,K) + 2Cov(I,K) This expression is dif cult to analyze without making simplifying assumptions. In this section we make simplifying assumptions that allow for a perspective on individual risk components. Cases are developed that allow us to focus on price risk and load risk separately In all of these cases the objective is to minimize the risk of a portfolio with market instruments. The use of market instruments to minimize risk is called hedging. The concept of risk mitigation is depicted in the following graphs. The rst graph in Figure 10.7 depicts the discrete probabilities of a given retailer portfolio,

This chapter focuses on one small part of IR. The three main ideas discussed are (1) the term-document matrix, a natural way to analyze the words in a collection of texts; (2) the idea of representing texts by vectors, and then applying geometric concepts; and (3) the TF-IDF for computing similarities between texts. Of course, IR has many other ideas and techniques beyond the vector space model. For further information on IR, here are three introductory books. First, Michael Berry and Murray Browne s Understanding Search Engines [ 101 has an excellent introduction to the vector space model. Second, David Grossman and Ophir Frieder s Information Retrieval [48] has a good overview of the many approaches of IR. Third, Dominic Widdows s Geometry and Meaning [ 1261 is a fascinating book that considers how to use geometry to analyze language, and his level of mathematics is similar to this book. Finally, for more information on linear algebra itself, my favorite book is Gilbert Strang s Linear Algebra and Its Applications [ 1131. In the next chapter, we turn to corpus linguistics, which studies language through the computer analysis of corpora (plural of corpus). These are collections of texts representative of an aspect of language.

Intellectual capital is a creation of the mind Before it can be protected or even used, it must be disclosed by its creators(s) More specifically, it must be disclosed to those who will be responsible for its use and those who will undertake to secure and protect it Proper disclosure is particularly important with respect to inventions that may be susceptible of protection by patenting or as trade secrets Obviously, no steps can be taken to protect an invention until its existence and nature are known Unless suitably encouraged and directed, many inventors will not disclose their inventions in such manner as to bring them to the prompt attention of those charged with securing and protecting them Some inventors are too busy with other tasks, or simply too lazy, to prepare a proper disclosure of their work.

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